How to use: First, get your Pandemic base game ready. Then, add the new event and role cards from this expansion to the base game's decks. If you're playing with five players, follow the new rules provided. You can choose to play with just one of the challenges or combine them for a tougher game. When setting up, make sure to understand the rules of each challenge. For example, when using the Virulent Strain challenge, be prepared for the disease to act in wild ways. With the Mutation challenge, learn how the purple disease works. In the Bio - Terrorist challenge, decide which player will take on the special role. Note: Keep the cards in a dry and cool place to prevent damage. Also, make sure all players understand the new rules before starting the game. When you're done playing, neatly stack the cards and put them back in the box for future use.